Winkleby Lab In the Prevention Research Center

National Institutes of Health, Small Grants Program, NHLBI: Hispanic and White Women’s Cardiovascular Health

RESEARCH SUMMARY:

This proposal includes several interrelated analyses that focus on three population subgroups that are among the most underrepresented in cardiovascular disease (CVD) epidemiologic research: women, Hispanics, and low socioeconomic status (SES) whites. The goal of the proposed analyses is to elucidate the interrelationships of ethnicity and SES on women's cardiovascular health, using recently completed risk factor and mortality data from the Stanford Five-City Project (FCP). This population-based intervention trial was carried out in five cities in California from 1979-1990 and has extensive questionnaire, physical measurement and surveillance data on children and adults, ages 12-74. There are two main aims, both of which extend the original FCP workscope. Aim #1 uses survey risk factor data (e.g., blood pressure, cholesterol, blood lipids, smoking, physical activity, dietary patterns) on over 4,500 girls and women, and Aim #2 uses surveillance mortality data on over 1,800 women to:

PROJECT AIMS:

Aim #1-a.  Test the hypothesis that there is a strong graded association between SES and CVD risk factors for both Hispanic and white women, with the most pronounced effect among women at the lowest SES levels.

Aim #1-b.  Test the hypothesis that Hispanic/white differences in CVD risk factors are attenuated but not eliminated in women after controlling for SES.

Aim #1-c.  Identify and characterize subgroups of low SES women from the Five-City Project's treatment cities who were the most likely (or unlikely) to make positive risk factor changes in response to the intervention.

Aim #2-a.  Estimate rates of CVD fatal events for Hispanic and white women by level of SES.

Aim #2-b.  Examine differences in the presentation, diagnosis and treatment of CVD fatal events for Hispanic and white women by level of SES.

 

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